Constipation Medications: OTC and Prescription Options

Tricyclic agents such as amitriptyline and imipramine were initially prescribed to IBS patients with significant depression. Today, they are frequently used to treat patients with severe or refractory IBS symptoms and may have analgesic and neuromodulatory benefits in addition to their psychotropic vicks on cotton ball in ear effects. In one trial, nearly 70 percent…