Evaluation of a multi-herb supplement for erectile dysfunction: a randomized double-blind, placebo-controlled study Full Text

Furthermore, structure-activity studies on the isolated compounds from African medicinal extracts will be of great interest. Inflammation is a complex mechanism with many pathways. Several extracts derived from medicinal plants have been shown to modulate or inhibit the activities of mediators of inflammation. Quercetin is a flavonoid molecule ubiquitous in nature and functions as an antioxidant and anti-inflammatory agent. Curcumin, a yellow pigment of turmeric, has been shown to exhibit anti-inflammatory activity.

Hence, although several assays are available, none of them is capable of accurately and completely determining the antioxidant activity of a test substance because of the complex nature of the redox-antioxidant system in vivo . Based on this complexity, antioxidants are broadly classified as inhibitors of free radical formation, free radical scavengers, cellular and tissue damage repairers, and signalling messengers . Several medicinal plant extracts were studied at research centres in African countries for their antioxidant caterwauling definition properties. Although known antioxidant compounds such as ascorbic acid have been confirmed to promote wound healing, not all the newly identified compounds have been tested for such activity [488–491]. Animal studies were also conducted to assess the antioxidant properties of several medicinal extracts. Some medicinal plant extracts were tested for their ability to protect against carbon tetrachloride-, 2-acetylaminofluorene- (2-AAF-), and galactosamine-induced liver as well as aflatoxin B1-(AFB1-)induced genotoxicity.

Zarzuelo, “Antidiarrhoeic activity of quercitrin in mice and rats,” Journal of Pharmacy and Pharmacology, vol. M. P. Germanò, R. Sanogo, M. Guglielmo, R. De Pasquale, G. Crisafi, and G. Bisignano, “Effects of Pteleopsis suberosa extracts on experimental gastric ulcers and Helicobacter pylori growth,” Journal of Ethnopharmacology, vol. Woldu, “Isoflavonoids from the roots of Salsola somalensis,” Phytochemistry, vol.

S. Amos, E. Kolawole, P. Akah, C. Wambebe, and K. Gamaniel, “Behavioral effects of the aqueous extract of Guiera senegalensis in mice and rats,” Phytomedicine, vol. N. Bouchet, L. Barrier, and B. Fauconneau, “Radical scavenging activity and antioxidant properties of tannins from Guiera senegalensisi ,” Phytotherapy Research, vol. V. K. Zishiri, Potentising and application of a Combretum woodii leaf extract with high antibacterial and antioxidant activity, University of Pretoria, 2005. S. F. Kouam, B. T. Ngadjui, K. Krohn, P. Wafo, A. Ajaz, and M.

Hence, it improves the erection function and premature ejaculation. It is also used in sexual creams to support erection. One of the common sexual dysfunctions in men is ED .

However, considering the small sized placebo effect observed in this study, the results described should be viewed with caution. It may have benefited the treatment results as significantly better, even if minimal. In clinical trials of drug treatments, placebo responses have often been substantial, usually significantly and statistically better than no treatment . K. O. Akinyemi, O. Oladapo, C. E. Okwara, C. C. Ibe, and K. A. Fasure, “Screening of crude extracts of six medicinal plants used in South-West Nigerian unorthodox medicine for anti-methicillin resistant Staphylococcus aureus activity,” BMC Complementary and Alternative Medicine, vol.

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