Effects of topiramate, bupropion and naltrexone isolated or combined on subcutaneous adipose tissue in obese rats PMC

With complex partial seizures, you may feel confused or dazed, and may be unaware of your surroundings. You may also have muscle twitching or a change in your senses, as mentioned above. The type of seizure you have depends on the part of your brain that’s affected. If you or someone you know is having thoughts of suicide, a prevention hotline can help. The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988.

These include slurred speech, memory problems, kidney failure, and muscle tremors or twitches. Many drugs in this class, including Topamax, are also effective for other conditions that don’t involve seizures. For children ages 2 to 16 years, the usual recommended daily dose is 5 mg to 9 mg per kg of body weight. One dose is taken in the morning, and the other dose is taken in the evening. For the first week of treatment, the starting dose per day is usually about 1 milligram to 3 mg per kilogram of body weight. Topamax was found effective in preventing migraine headaches in clinical trials.

Topamax isn’t approved to treat alcoholism, which is also called alcohol dependence or alcohol use disorder. However, the drug may sometimes be used off-label to treat this condition. Another small study found Topamax to be effective for treating OCD in people with bipolar disorder. A clinical study found Topamax to be effective for treating partial-onset and generalized tonic-clonic seizures when used alone. Migraine episodes can be treated with medications that help relieve the symptoms.

With either drug, weight loss can result in low blood sugar. Report side effects or any changes that concern you to your doctor. Phentermine have some similar side effects, such as stomach problems, headache, and difficulty sleeping.

Based on this small number of Black/African American patients, it appears that Black/African American patients had inferior weight loss outcomes, although this finding needs to be confirmed in a larger cohort. Similarly, the fact that women were largely overrepresented in some of the studies analyzed makes the generalizability to men unclear. Prospective study of intentional linguistics major uf weight loss and mortality in never-smoking overweight US white women aged 40–64 years. Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity. This medicine may cause your body temperature to go down especially when taking valproic acid, which is a medicine to control seizures.

However, taking the two drugs together could raise your risk for the side effects mentioned above. For this reason, you should avoid CNS depressants while taking Topamax. Note that Wellbutrin XL and Wellbutrin SR are both approved to treat depression in adults.

Aronne et al. evaluated Phentermine and Topiramate compared to a combination of these drugs in a 28-week. Consistent with our results, they concluded that the combination of these drugs produced more weight loss than when each was used as a separate treatment . A study by Smith et al. introduced the combination weight-loss drug Phentermine + Topiramate as a dietary supplement to manage the weight of obese or overweight patients and weight-related diseases . According to PRISMA guidelines, studies conducted in the field of drug treatment for obesity were systematically reviewed. Based on the initial search in the reviewed databases, 1456 studies were collected and transferred to the information management software . Of these, 130 were repeated studies, 522 were unrelated, and 793 were excluded by reviewing the title and abstract based on inclusion and exclusion criteria.

These side effects include drowsiness, dizziness, irregular heartbeats, and seizures. Anticholinergic drugs are used to treat many different conditions, including overactive bladder, asthma, and Parkinson’s disease. Therefore, taking Topamax with anticholinergic drugs could raise your risk for overheating and hyperthermia , especially in hot weather. There have been no studies involving people who took Topamax with a CNS depressant.

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